IS IT NEED A CRITERION LDL CHOLESTEROL IN DEFINITION OF METABOLIC SYNDROME?
Yu.P. Nikitin1, G.I. Simonova1, K.K. Sozonova2, O.V. Tatarinova3
1Institution of Internal and Preventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Republican Hospital N3, Geriatric Centre, 677000, Yakutsk, Pokrovsky highway, 8 km
3Yakut Scientific Centre of Complex Medical Problems of SB RAMS, 677010, Yakutsk, Sergelyakhskoe highway, 4
Keywords: metabolic syndrome, blood lipids, hyper-LDL-cholesterol
Abstract
The average content of LDL cholesterol obtained 138.8±39.3 mg/dl, in natives, but non-natives have obtained similar values: 137.7±38.5 and 140.8±40.0 ( р
n-nn = 0.56) in the general population sample of olders ( n = 485 pers.). Average values of LDL cholesterol content in group without metabolic syndrome (MS-) obtained 126.1±42.1 mg/dl, in MS(+) group - 150.7±32.4 mg/dl ( р = 0.0001) by RSSC 2009. Determine the frequency of elevated levels of LDL cholesterol (≥115 mg/dl) is 72.4 % in the general population, without significant difference between natives and non-natives. In MS(+) and MS(-) groups, the results of the frequency of hyper-LDL cholesterol obtained close in five definitions of MS. The differences in figures are not large and statistically significant ( p > 0.1). And in only one case (by RSSC analysis) differences in the values of hyper-LDL between MS(+) and MS(-) groups received significant. Conclusion: High level of LDL cholesterol in all MS definitions has no significant differences in the frequency in MS(+) and MS(-) groups of elderly urban population of Yakutia, and also in comparison with population values of hyper-LDL. It allows to recognize that there is no reason to recommend in medical practice the use of the criterion LDL cholesterol in MS diagnosis.
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