Are there any differences in optical properties of blood, associated with the degree of arterial hypertension?
M.V. Kruchinina1, A.A. Gromov1, A.V. Rabko1, V.A. Baum1, V.M. Generalov2, V.N. Kruchinin3, S.V. Rykhlitsky3, V.A. Volodin3
1Institute of Internal and Priventive Medicine of SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2State Research Center of Virology and Biotechnology В«Vector», 633159, Novosibirsk, Koltsovo
3Institute of semiconductor physics n.a. A.V. Rzhanov of SB RAS, 630090, Novosibirsk, Academic Lavrent’ev av., 13
Keywords: hypertension, degree, erythrocytes, electrical and viscoelasticparametersdielectrophoresis, theoptical parameters of blood serum, ellipsometry, Raman-spectroscopy
Abstract
We investigated the electrical and viscoelastic parameters of red blood cells, optical parameters of blood serum in patients with hypertension of I and II degree. We marked the increase of variations in the optical characteristics of blood components with an increase in the degree of hypertension. We identified the correlations of erythrocytes parameters with biochemical indicators reflecting hyperlipidemia, microalbuminuria and the presence of inflammation. It was noted that the velocity of red blood cells to the electrodes, the dipolemoment can be the markers of initial stages of endothelial dysfunction. It was suggested that the decrease of deformability, surface charge of red blood cells are the important pathogenetic factors in the progression of hypertension, therefore, requires additional emphasis in the treatment of this disease. The identified relationships between the optical parameters of erythrocytes and serum indicators confirm the interaction between their components, and require complex treatment of hypertension.
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