ASSOCIATION SINGLE NUCLEOTIDE POLYMORPHISMS OF GENE LIPID METABOLISM
APOE, HL, SREBP2, USF1 WITH SUDDEN CARDIAC DEATH BY RUSSIAN POPULATION
V.N. Maksimov1, A.A. Ivanova1, P.S. Orlov2,3, E.V. Shakhtchneyder1, D.E. Ivanoshchuk2,3, S.V. Savchenko4,5, M.I. Voevoda2,3
1Institute of internal and preventive medicine SB RAMS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Institute of internal and preventive medicine SB RAMS, 630090, Novosibirsk, Academic Lavrent`ev av., 10
3Institute of Cytology and Genetics SD RAS
4Novosibirsk State Medical University, 630091, Novosibirsk, Krasny av., 52
5Novosibirsk Regional Bureau of Forensic Medicine, 630087, Novosibirsk, Nemirovich-Danchenko str., 134
Keywords: sudden cardiac death, a single nucleotide polymorphism, E2/E3/E4 gene APOE, rs1800588 gene HL, rs2228314 gene SREBP2, rs2516839 gene USF1
Abstract
Study objective. Investigate the association of polymorphisms E2/E3/E4 gene APOE , rs1800588 gene HL , rs2228314 gene SREBP2 , rs2516839 gene USF1 with sudden cardiac death in the Russian population. Materials and methods. A group of sudden cardiac death ( n = 379), the control group, matched by sex and age ( n = 352). Results and discussion. The frequencies of genotypes E2/E3/E4 gene APOE , rs1800588 gene HL , rs2516839 gene USF1 was not found statistically significant differences between the groups. The frequencies of genotypes rs2228314 gene SREBP2 found statistically significant differences between the group of sudden cardiac death and the control group. GC genotype is conditionally protective against the development of sudden cardiac death (OR = 0.4, 95 % CI 0.3-0.6, p = 0.0). CC genotype is associated with an increased risk of sudden cardiac death in men (OR = 4.1, 95 %CI 1.8-9.0, p = 0.0). Conclusion. rs2228314 gene SREBP2 is associated with sudden cardiac death in the Russian population.
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