Mechanochemical Preparation of the Composites of Betulin Esters with Arabinogalactan and Investigation of Their Physicochemical Properties
S. A. KUZNETSOVA1,2, YU. N. MALYAR1, T. P. SHAKHTSHNEIDER3,4, M. A. MIKHAILENKO3, V. A. DREBUSCHAK4,5 and V. V. BOLDYREV3,4
1Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences, Ul. K. Marksa 42, Krasnoyarsk 660049 (Russia)
E-mail: ksa@icct.ru
2Siberian Federal University, Pr. Svobodny 79, Krasnoyarsk 664041 (Russia)
3Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia)
4Novosibirsk State University, Ul. Pirogova 2, Novosibirsk 630090 (Russia)
5Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences, Pr. Akademika Koptyuga 3, Novosibirsk 630090 (Russia)
Keywords: betulin diacetate, betulin dipropionate, arabinogalactan, mechanochemical treatment, dissolution, gel-permeation chromatography
Pages: 609–614
Abstract
Mechanically activated composites of betulin diacetate and dipropionate with water-soluble natural polysaccharide arabinogalactan were obtained. It was established that the composites are characterized by increased concentration of betulin diacyls during their dissolution in water. The formation of molecular complexes of betulin diacetate and dipropionate with arabinogalactan during mechanical activation and during the dissolution of initial and mechanically activated mixtures in water was assumed. The complexes of betulin diacyls with arabinogalactan were also obtained in the form of thin films, readily soluble in water.
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