HIGH-DENSITY LIPOPROTEIN, AND APOLIPOPROTEIN A-I: A REGULATORY ROLE AND NOVEL THERAPEUTIC STRATEGIES FOR THE TREATMENT ATHEROSCLEROSIS
L.M. Polyakov, L.E. Panin
Keywords: atherosclerosis, high density lipoprotein, apolipoprotein A-I, the regulatory role of apoA-I-mimetic peptides, treatment strategies
Abstract
In the review show the functions of high-density lipoprotein, is not related to the exchangeof lipids within them. The results own research, as well as literary evidenced of the important regulatory role. Regulatory effect of HDL is closely related to their antiatherogenic properties. However, it should be noted that the mechanism of action of antiatherogenic HDL is not limited to a “reverse” transport of cholesterol from peripheral tissues to the liver, it is determined by many other factors, all of which is important not only in the context of defense against atherosclerosis, but also in the protective role of HDL in a broader sense. The data show that HDL has an important antiinflammatory effect, have antioxidant and antiapoptotic properties, regulate vascular tone and anticoagulant activity, act as antimicrobial and antiviral agents. Due to the urgency of the problem of atherosclerosis in the emphasis that understanding the molecular mechanisms of the regulatory properties of HDL opens up new prospects for the development of more effective treatments for this disease. New treatment strategies should include the development of promising therapeutic approaches that modulate HDL metabolism, which would increase their levels in the blood and improve the “reverse” cholesterol transport. This review deals with, in our opinion, the two most promising areas – is the creation and use of recombinant HDL or reconstructed, as well as peptide-mimetics of apolipoprotein A-I
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