THE APPOINTMENT OF STATINS IN PATIENTS WITH HYPOTHYROIDISM: POSSIBLE RISKS
O.D. Rymar, S.V. Mustafina, Ya.A. Malyshenko
Keywords: hypothyroidism, statins, L-thyroxin, rhabdomyolysis, thyroid
Pages: 32-38
Abstract
Thyroid dysfunction and dyslipidemia are closely connected by pathogenetic reason. During the last few years they have been discussing L-thyroxin influence on lipid profile. According to data obtained in various studies, lipid profile values normalization appears not in every case of euthyroidism. In the literature there is little information about statins administration risk and advantage during hypothyroidism. According to the literature, decompensated hypothyroidism can lead to myalgia and/or myopathy development accompanied by creatine phosphokinase concentration increase in patients on statins. There are several publications of clinical cases of rhabdomyolysis development against the statins treatment background in persons with undiagnosed decompensated manifest hypothyroidism. Thus, taking into account the risk of the rhabdomyolysis development, TSH level should be estimated before statins treatment almost in all cases.
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