Atherogenic lipid disorders in adolescence: long-term population study in Novosibirsk (1989-2009)
D.V. Denisova, L.G. Zavyalova, M.V. Ivanova
Keywords: blood lipid profile, dislipidemias, trends, adolescents, population
Pages: 5-13
Abstract
Objective of the study was to examine 20-year trend in the prevalence of atherogenic lipid disorders in adolescents 14-17 years - residents of a large Russian industrial city (Novosibirsk). Methods. Five cross-sectional population surveys of representative samples of schoolchildren aged 14-17 of both sexes were conducted during the period from 1989 to 2009. The study sample included 3311 adolescents (43 % boys) with the response rate 88-93 %. Blood total cholesterol, high-density lipoprotein cholesterol, triglycerides, were measured by enzymatic methods. Low-density lipoprotein cholesterol was calculated with Friedwald's formula. Prevalence of dyslipidemia was evaluated with NCEP-peds criteria. Results. During the period from 1989 to 2009 blood lipid profile in adolescents 14-17 years has changed significantly. Mean levels of total cholesterol and low-density lipoprotein cholesterol decreased significantly in both gender groups. Mean values of high-density lipoprotein cholesterol for the 20-year period did not changed. Frequency of hypercholesterolemia for twenty years has fallen by more than 5 times. Significant regression coefficients for total cholesterol controlled by age, sex and year of study were revealed with body mass index, diastolic blood pressure and triceps skinfolds. Conclusion. During the period from 1989 to 2009 the prevalence of atherogenic dislipidemias among adolescents of Novosibirsk significantly changed.
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