Publishing House SB RAS:

Publishing House SB RAS:

Address of the Publishing House SB RAS:
Morskoy pr. 2, 630090 Novosibirsk, Russia



Advanced Search

The journal "Ateroskleroz"

2011 year, number 2

STRESS-MEDIATED MECHANISMS OF METABOLIC SYNDROME DEVELOPMENT: THE ROLE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS

M.V. Khrapova, M.I. Dushkin
Keywords: PPAR, stress, metabolic syndrome
Pages: 15-24

Abstract

Some aspects of peroxisome proliferator activated receptors (PPAR) involvement in regulation of stress-dependent biological processes leading to insulin resistance, lipid imbalance, hypertension and inflammation are reviewed. Analysis of literature data clearly shows the main role of PPAR in stress signal transduction following to metabolic disbalance development under prolonged stress conditions. The interplay of three PPAR isoforms functional activity with metabolic process disturbances during stress is under special emphasis. Taking into account experimental data described in literature we suggest that PPAR activation under acute stress is an adaptive response while stable PPAR hyperexpression under proloned stress can cause insulin resistance, hypertension, and visceral obesity. The strategy of PPAR using as pharmacological targets in metabolic syndrome correction is under consideration.