APPLICATION OF MINI-PIGS AS A MODEL FOR DEVELOPING NEW METHODS OF ISCHEMIC HEART DISEASE (IHD) TREATMENT
V.N. Tikhonov, P.M. Larionov, A.V. Tikhonov
Keywords: mini- and micro-pigs, atherosclerosis, ischemic heart disease (IHD), xenotransplantation
Pages: 28-39
Abstract
At the last 30 years the application of the new laboratory species mini-pigs is progressively increasing in medical and biological research of atherosclerosis and other disorders of cardiovascular system. Mini-pigs differ from traditional experimental animals in maximal similarity of their anatomy and physiological functions of cardiovascular, digestive, excretory, and nervous systems with human ones. In the Institute of Cytology and Genetics SB RAS the specialized laboratory mini- and micro-pigs adapted for using under our conditions were created. In 2010 several hundreds of studies on mini-pigs were conducted in Russian Federation and abroad. The present review highlights some experimental works that could be applied for wide use in medicine.
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