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The journal "Ateroskleroz"

2010 year, number 2

ASSOCIATION OF POLYMORPHISM apolipoprotein A1 With the lipid profile SERUM

E.V. Schakhtschneider, I.V. Kulikov, M.V. Ivanova, M.I. Voevoda
Keywords: apolipoprotein AI gene, HDL, high-density lipoprotein cholesterol, promoter polymorphism, plasma lipids, population
Pages: 5-9

Abstract

Objective: to investigate apolipoprotein AI gene polymorphism and its associations with lipid profile in Caucasian population of West Siberia. The study included 100 persons with total cholesterol >300mg/dl, 100 - with total cholesterol <200mg/dl) and 100 - with total cholesterol 233,6±47,7mg/dl aged 45-64 from sample of Novosibirsk population. The apolipoprotein A1 polymorphism was analyzed by standard method using PCR. The serum lipid levels were determined by standard enzymatic assays. Analysis of promoter polymorphism apolipoprotein A1 (APOAI) gene in three groups showed statistical significance associations between -75G>А of APOAI gene and some key lipid risk factors (total blood cholesterol, low density lipoproteins cholesterol, index of atherogenity) in people of West-Siberian region. The genotype AA has been associated with higher blood lipid levels in population of West Siberia.