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The journal "Ateroskleroz"

2010 year, number 1

Lipoprotein(A) and multi-stage atherogenesis: coronary atherosclerosis, cerebrovascular complications and other correlations of LP(A) and APO(a)

A.V. Tikhonov, YU.P. Nikitin
Research Institute of Therapy of SB RAMS
Keywords: atherosclerosis, genetics, lipid metabolism, lipoprotein(a), apoa isoforms
Pages: 34-42

Abstract

A connection of the level of Lp(a) with the presence and extent of atherosclerosis of main arteries of head was proved. It was demonstrated that this level in the patients who survived stroke is reliably higher than that in the patients from reference groups. A direct connection of low-molecular phenotypes of apo(a) with the presence, extent and development of atherosclerotic affection of carotid arteries was also proved. hypertension is a significant and independent risk factor of coronary heart disease. Other factors of cardiovascular risk including disorders of lipid metabolism, added to arterial hypertension, increase the probability of the development of coronary heart disease even to the higher extent.