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The journal "Ateroskleroz"

2008 year, number 1

1.
SOME MOLECULAR BIOLOGICAL MECHANISMS OF ATHEROSCLEROSIS

YU.P. Nikitim1, M.I. Dushkim1, YU.L. Raginoi1, A.G. Romascbenko2, M.I. Voevodai3
1 lnstitute of Internal Medicine SB RAMS
2 lnstitute of Cytology and Genetics SB RAS
3 lnstitute of Internal Medicine SB RAMS; lnstitute of Cytology and Genetics SB RAS
Pages: 3-10

Abstract >>
The current data on some molecular cellular and molecular genetic mechanisms of atherosclerosis and its complications have been presented in the research. Taking into account the significance of lipid transport system for initiation of atherosclerosis plaques we point to major role of lipoprotein modified forms in atherogenesis. Information of key mediators of macrophage transformation into foam cells has been produced. The results of original investigation of some genes' polymorphism analysis in ethnic groups in Siberia and its connection with ischemic heart disease have been represented.
																								



2.
POLYMORPHISM OF APOLIPOPROTEIN E GENE AND ATHEROSCLEROSIS

M.I. Voevodai1, E.V. Schakhtschneiden2, V.N. Maximovi2, I.V. Kulikovi2, A.G. Romaschenko3
1 Institute of Internal Medicine SB RAMS; Institute of Cytology and Genetics SB RAS
2 1nstitute of Internal Medicine SB RAMS
3 Institute of Cytology and Genetics SB RAS
Keywords: atherosclerosis, apolipoprotein E, gene, polymorphism, population frequency, promoter, sudden death, myocardial infarction, stroke, long-lives
Pages: 11-26

Abstract >>
Polymorphism genes assay is of importance for estimation of predisposition to multifactorial diseases on population and individual level. We investigated apolipoprotein E polymorphism and its influence on a lipid metabolism in population of Novosibirsk city (the largest scientific and industrial centre of West Siberia). Polymorphism of apolipoprotein E (APOE) gene was studied in sample of inhabitants of Novosibirsk city aged 25-64 years (n=6n), in patients with nonfatal myocardial infarction (11=141), in patients with nonfatal stroke (11=167), in men with sudden cardiac death (n=2^o) and in long-livers of the same region (n=gy). A lipid profile depending on APOE genotypes was analyzed in a population and in a group of long-livers of Novosibirsk. In male population 25-64 years of age dynamics (changes) of frequencies APOE genotypes are not revealed. In comparison with frequencies of APOE genotypes in men is more senior than 83 years has appeared, that the frequency of a genotype Ј^Ј4 has decreased 4 times, and the frequency of a genotype Ј2/ез has increased 2 times. Among the persons of senile age and long-livers, both men, and women the carriers of a genotype Ј4/Ј4 on APOE gene are not revealed. The highest level of total cholesterol in population of Novosibirsk is characteristic for a genotype APOE Ј4/Ј4. The introduction of genotyping of human apolipoprotein E in a population of Novosibirsk is expedient.
																								



3.
Age- and gender-specific gradient of arterial wall intima-media

A.N. Ryabikov, M.N. Ryabikov, S.K. Malyutina
Institute of Internal Medicine SB RAMS
Keywords: intima-media, carotid artery, atherosclerosis, age gradient, gender gradient, population, ultrasonography
Pages: 27-32

Abstract >>
Arterial intima-media thickness (IMT) is qualitative and quantitative marker of generalized atherosclerosis as well as a predictor of CVD strongly associated with the presence and level of CVD risk-factors. In the frame of a Siberian WHO MONICA Project and European Project on Genes in Hypertension (EPOGrfJ the representative population sample aged 18-63 (658 pers., mean age - 41.9 yrs) was examined by standard epidemiological methods followed by high-resolution carotid ultrasonography. The mean age-standardized IMT in men was significantly higher than in women (0.64+0.007 vs 0.5S+ 0.012, p<o.ooi). The IMT range in men was of 0.30-1.70 mm, io%- and 90% cut-off points of the IMT distribution were 0.50 and 0.90 mm, correspondently. In women IMT range was of 0.30-1.30 mm, 10%- and 90% cut-off points of the IMT distribution were 0.40 and 0.80 mm, respectively. IMT consequently increased by age in both sexes, and was more remarkable in men (p<o.ooi). The growth of IMT by decade varied in men and women from 0.005 t0 °-17 mm- The most intensive IMT increase was observed in men, particularly in 35-44 year decade, comparing to women. Carotid IMT in a Siberian city population is similar to ones in North American and some European populations (Netherlands, Germany) and is higher than in France and Japan. The mean IMT and its growth intensity are higher in men than in women up to the age of 55 when increase rate became equal in both sexes. The sex-specific differences in early atherosclerotic morphology revealed by ultrasound may contribute to excess of coronary risk in middle age Siberian men.