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The journal "Ateroskleroz"

2006 year, number 1

1.
MODIFIED LOW DENSITY LIPOPROTEINS AND ATHEROSCLEROSIS

YU.I. Ragino, YU.P. Nikitin
Institute of Internal Medicine SB RAMS
Pages: 3-19

Abstract >>
Oxidized and structural modified low density lipoproteins (LDL) in atherosclerosis and some main risk factors were studied. Similar atherogenic oxidized and structural changes of LDL were revealed both of coronary atherosclerosis and of it main risk factors such us hyperlipidaemia, arterial hypertension and diabetes mellitus. These results confirm that modified LDL play a key role in atherogenesis.
																								



2.
ATHEROSCLEROSIS AND DISELEMENTOSISES

E.YA. Zhuravskaya1, K.P. Koutzenogii2, L.A. Gyrgolkay1
1 Institute of Internal Medicine SB RAMS
2 Institute of Chemical Kinetics and Combustion
Pages: 20-26

Abstract >>
The multielement composition of blood in men aged 34-54 with atherosclerosis and coronary heart disease was investigated by SRXRF method. The significance difference in the content of chemical elements was revealed in this group compared with group without coronary heart disease. Some changes were found in the content of chemical elements in men with disorder in lipid metabolism. These data have diagnostic and prognostic importance's.
																								



3.
Atherogenic lipid disorders among adolescents

D.V. Denissova, L.G. Zavjalova
Institute of Internal Medicine SB RAMS
Novosibirsk, Novosibirsk
Pages: 27-32

Abstract >>
Hyperlipidemia is a known risk factor of coronary artery disease. The reduction of elevated serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in childhood may reduce cardiovascular morbidity and mortality in adulthood. Aim of the study was to assess prevalence and trends in lipid profile and lipid disorders of adolescent population in Novosibirsk (1989-2003). Methods: Four cross-sectional surveys of school children aged 14-17 in 1989 (656), in 1994 (620), in 1999 (626) and in 2003 (667) were carried out. Total sample was 2569 (1214 males and 1355 females). Blood total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), were measured by enzymatic methods. LDL-C was calculated with Friedwald's formula. Associations of blood lipids with age, sex, year of study, body mass index (kg/m2), blood pressure and main nutrients of diet were measured by GLM method. Prevalence of dyslipidemia was evaluated with NCEP-peds criteria. Diet was estimated using 24-hour dietary recall. Results. During the 15-year period (1989-2003) mean serum TC decreased from 175 to 162 mg/dl in males and from 191 to 175 mg/dl in females (P < 0,001). Average levels of LDL-C also have fallen significantly during the period, but no changes in HDL-C levels were found. Females had significantly higher mean TC and LDL-C than did males at all surveys (P < 0,001). According to NCEP-peds criteria, prevalence of high TC (200 mg/dl and more) during the period (1989-2003) significantly decreased from 22% to 8 % (P < 0,01) in males and from 32 % to 17 % (P < 0,05) in females. Frequencies of low HDL-C (<40 mg/dl) also decreased in boys and girls (P < 0,05 for both gender groups). Significant regression coefficients for TC controlled by age, sex and year of study were revealed with body mass index, diastolic blood pressure and triceps skinfolds. Trends in diet during the period showed significant decreasing of total energy and basic nutrient intakes (proteins, fats and carbohydrates). Conclusion. During the period of socioeconomic reforms in Russia (1989-2003) the lipid profile and prevalence of atherogenic dislipidemias in adolescents of Novosibirsk significantly changed following by changes of body mass index and diet.