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Contemporary Problems of Ecology

2009 year, number 3

Manifestations of Structural-Metabolic Adaptation During the Primary Compensatory Adaptive Reaction of Hepatocytes in Birds of Columba livia Species After Hyperthermia

E. I. Antonova
Keywords: liver, hepathocytes, hyperthermia, birds, chromatin, Krebs cycle, caspase-3
Pages: 413-422

Abstract

Cytophysiological compensations of the rapid response for short-term single ambient temperature rise in the birds of Columba livia species, according to the hypothesis of «energy need», are realized in hepathocytes due to the development of the metabolic depression which is expressed as a decrease in the activity of the enzymes involved in Krebs cycle and their cytoplasmic forms. The activity of G-6-FDG increases, as the index of the adaptive metabolic plasticity, activation of the antioxidant system. The flow of metabolites is observed to switch from the aerobic route of glucose oxidation to the anaerobic one, the process of programmed cell death on the way of apoptosis is activated, the fraction of hepathocyte population at the G0 stage increases, while the fraction of hepathocytes at M stage of the cell cycle correspodns to the corresponding index in the intact individuals.