EFFECT OF caffeine on DNA conformational changes AFTER IN VITRO Оі-irradiation
S. V. Paston, A. E. Tarasov
Keywords: caffeine, DNA, ? irradiation, radioprotectors, radiosensitizers, spectrоphotometric analysis, DNA secondary structure
Pages: 1246-1251
Abstract
The radioprotective action of caffeine upon γ irradiation of DNA solutions is demonstrated by means of low gradient viscometry, flow birefringence, atomic force microscopy and UV spectroscopy. In the presence of caffeine, a decrease in the radiation effect on the DNA coil size in the solution, in the number of double-stranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.
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