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Journal of Structural Chemistry

2010 year, number 6

stereoisomeric complexes of Pt(II) with threonine and allothreonine

Keywords: stereoisomers, complexes, platinum, threonine, allothreonine, NMR spectra, IR spectra, crystal structure
Pages: 1187-1199


The paper describes the synthesis of geometrical isomers and diastereomers of Pt(II) bischelates with diastereomeric hydroxy-amino acids threonine (threo-α-amino-β-hydroxybutyric acid CH3C*H(OH)C*H(NH2)COOH=ThrH) and allothreonine (erythro-α-amino-β-hydroxybutyric acid=alloThrH) containing two asymmetric carbon atoms C*: cis-,trans-[Pt(S-Thr)2], cis-,trans-[Pt(R-Thr)(S-Thr)], cis-,trans-[Pt(R-alloThr)(S-alloThr)] (where R and S are the absolute configurations of the asymmetric carbon atom bonded to the carboxyl group). 195Pt NMR spectroscopy is used to investigate the successive phases of the synthesis of the stereoisomeric Pt(II) complexes with threonine. The synthesized complexes are studied by 1H, 13C, 195Pt NMR spectroscopy, IR spectroscopy, and single crystal XRD.