Conformational Polymorphism in Racemic 2,4-Di-O-Benzoyl-6-O-Tosyl myo-Inositol 1,3,5-Orthoacetate
K. Manoj, R.G. Gonnade, M.M. Bhadbhade, M.S. Shashidhar
Keywords: conformation, crystal structure, dipolar interactions, inositol, non-covalent interactions, polymorphism, sulfonyl-carbonyl contact
Pages: 753-758
Abstract
The title compound, C29H26O10S, yields two conformational polymorphs concomitantly fr om dichloromethane-methanol mixture; the major polymorph grows as plates (Form I, monoclinic, P21/n) and the minor polymorph grows as needles (Form II, triclinic, P-1). The two forms differ mainly in orientation of the tosyl group. In Form I, sulfonyl oxygen of the tosyl group makes intermolecular C-H?KO interactions, wh ereas the same group in Form II is involved in an intramolecular short dipolar S=O?KC=O (sulfonyl-carbonyl) contact. The molecular organization and the influence of various weak non-covalent interactions that stabilize these conformers in the crystal lattices are discussed.
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