CRYSTAL STRUCTURES OF ALKALOID PEGANINE AND ITS COCRYSTAL WITH PEGANOL
R. Y. Okmanov, A. G. Tozhiboev, K. K. Turgunov, B. Tashkhodzhaev, Z. M. Khakimova, T. S. Tulyaganov, K. M. Shakhidoyatov
Keywords: quinazolines, peganine, peganol, salts, cocrystals, X-ray diffraction
Pages: 1203-1208
Abstract
X-ray diffraction (XRD) is used to investigate the crystal structures of the alkaloid peganine, its hemihydrate and nitrate. It is shown that (±)-peganine forms a cocrystal with the alkaloid peganol. It is typical of the alkaloid (-)-peganine crystal structures to form a closed dimer pair because of reciprocal O-Н…N1 hydrogen bonds. Analogous H-bonds are also observed in the (±)-peganine-(±)-peganol cocrystal, where the center of symmetry binds together similar molecules to form associates. In (±)-peganine nitrate crystals, the NH+ and ОН groups of the alkaloid form H-bonds simultaneously with two oxygen atoms of nitric acid anions.
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