Home – Home – Jornals – Journal of Structural Chemistry 2009 number 5

The interactions of palladium cation−anion compounds (C₄H₁₀NO)₂[PdCl₄], K₂[PdCl₄], and K₂[PdBr₄] with DNA in 0.005 M NaCl and 0.15 M NaCl solutions were studied by spectrophotometry, circular dichroism, viscosimetry, dynamic birefringence, and atomic force microscopy. The interactions are primarily effected by coordination of the donor atoms of DNA bases by palladium. The end products of interactions with palladium acido complexes are independent of the macromolecule and the nature of halogen X in [PdX₄]^2-. The significant changes in the conformation of DNA in palladium complexes resulted from both intra- and intermolecular cross-linkings induced by palladium.