COMPLEXES OF FERROMAGNETIC FLUIDS WITH PHOTODITAZIN AND THEIR PROMISING APPLICATIONS IN PHOTODYNAMIC THERAPY
Y. V. Kulvelis, V. A. Trunov, V. T. Lebedev, D. N. Orlova, D. Torok, M. L. Gelfond
Keywords: photodynamic therapy (PDT), photoditazin, magnetic fluids, neutron scattering
Pages: 986-990
Abstract
Nanosized complexes of ferroparticles with a sensitizer photoditazin (used in photodynamic therapy in oncology) have been synthesized and studied by small-angle neutron scattering. The structure of the complexes was determined, and the influence of the biocompatible polymer pluronic investigated. Clinical tests revealed increased efficiency of the complexes compared with the starting photoditazin. The complexes can be used as the first magnetically operated sensitizer for treatment of oncological diseases by photodynamic therapy.
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