Mechanochemical Preparation and Properties of Water-Soluble Intermolecular Complexes of Polysaccharides and ОІ-Cyclodextrin with Pharmaceutical Substances
A. V. Dushkin1, E. S. Meteleva1, T. G. Tolstikova2, M. V. Khvostov2, G. A. Tolstikov2
1 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences
2 Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
dushkin@solid.nsc.ru, tg_tolstikova@mail.ru
Keywords: water-soluble supramolecular complexes, arabinogalactan, ?-cyclodextrin, polysaccharides, pharmacological properties, mechanical destruction, low-soluble pharmaceutical substances
Pages: 631-640
Abstract
Comparative investigation of obtaining conditions and the "stability" of water-soluble intermolecular complexes of low-soluble pharmaceutical substances and different polysaccharides with β-cyclodextrin was carried out. Substantial improvement of the pharmacological characteristics of resulting complexes in comparison with initial pharmaceutical substances was demonstrated.
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