Determination of the Physicochemical Characteristics and Biological Activity in vitro of the Composite Са-Р/Chitosan Coating Obtained by Means of Electrochemical Deposition
Y. A. Kamenchuk1, E. A. Zelichenko2, V. V. Guzeev1, A. B. Shashkin2, I. A. Khlusov1, K. V. Zaitsev1
1 Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Tomsk Branch
2 Biotekhnika Co
Yana100@inbox.ru
Keywords: chitosan, hydroxyapatite, electrochemical deposition, composite coating, stromal stem cells, osteogenic properties
Pages: 493-498
Abstract
Physicochemical and biological properties of the composite calcium phosphate chitosan coating are investigated. It is shown that the introduction of chitosan increases the concentration of the amorphous phase composed of nanosized particles; an increase in its concentration leads to changes of the thickness and roughness of the coating. It was revealed that during obtaining the composite coating by means of electrochemical deposition, chitosan and Са-Р get deposited onto the surface of titanium substrate interchanging chaotically and mutually supplementing each other, with the formation of a net structure. The СаР/Ch composites modulate in vitro and in vivo the functional activity and differentiation of stromal stem cells in the osteogenic direction, due to which they are promising in the aspect of developing new class of implants for orthopaedics and traumatology.
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