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Chemistry for Sustainable Development

2009 year, number 3

Synthesis of Bismuth (III) Oxide-Salicylate from its Nitrate Solutions for Medical Purposes

E. V. Timakova, Y. M. Yukhin, T. A. Udalova
Keywords: bismuth (III) oxide-salicylate, synthesis, IR and Raman spectra, thermal analysis
Pages: 313-321


Precipitation of bismuth salicylate from its nitrate solutions and the interaction of trihydroxo-pentaocohexabismuth (III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5 ⋅ 3H2O with the solutions of sodium salicylate and salicylic acid was studied by means of X-ray phase analysis, IR and Raman spectroscopy, thermogravimetry and chemical analysis. The dependence of the rate of nitrate ion exchange for salicylate ions on temperature and pH of the medium was investigated. The conditions of the formation of bismuth (III) oxide-salicylate of he composition Bi(C7H5O3)О were determined for precipitation from nitrate solutions and for the solid-to-solution reaction. It is shown that it is reasonable to synthesize these preparations of high purity for use as a drug substance in antiulcer and antidiarrheic preparations by means of the interaction of [Bi6O5(OH)3](NO3)5 ⋅ 3H2O with the solution of salicylic acid.