Mechanochemical Synthesis of Nonstoichiometric and Substituted Apatites with Nanosized Particles for Use as Biologically Compatible Materials
MARINA V. CHAIKINA1, IGOR A. KHLUSOV2, ANATOLIY V. KARLOV2 and KONSTANTIN S. PAICHADZE1
1Institute of Solid State Chemistry and Mechanochemistry,
Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia), E-mail: chaikina@solid.nsk.su
2Orthopedy and Medical Materials Science Center, Russian Academy of Medical Sciences,
Ul. Plekhanova 5, Tomsk 634029 (Russia)
Pages: 385-394
Abstract
Isomorphic varieties of substituted apatite have been synthesized mechanochemically for evaluating the applicability of the synthesized samples as biologically compatible materials. Mechanical treatment of reaction mixtures in a planetary apparatus for 5-30 min gave the final nanosized crystalline products synthesized directly in an activator. We have synthesized calcium- and phosphorus-deficient nonstoichiometric apatites, stoichiometric hydroxylapatite, hydroxylapatite with superstoichiometric potassium, zinc, and copper ions introduced in its structure, as well as apatites with potassium partially replaced by magnesium and barium. The kinetics of mechanochemical synthesis is affected by water, which stabilizes the structure of apatite. The results of bioactivity and cytotoxicity tests are given. Apatites synthesized mechanochemically may be used as biologically compatible materials.
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