Ureas and imidazolidine-2,4,5-triones containing 2-adamantyl fragment and residues of perillyl alcohol and myrtenol
P. E. ROGOZIN, E. V. SUSLOV, K. P. VOLCHO, N. F. SALAKHUTDINOV
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Keywords: adamantane, monoterpenes, perillyl alcohol, myrtenal, urea, oxalylurea
Abstract
The work is concerned with the synthesis of biologically active substances based on monoterpenoids through their chemical modification to increase the pharmacological potential of the synthesised compounds. The starting substances to synthesise urea derivatives were adamant-1-ylisocyanate and monoterpenoid amines with a perillyl or myrtenol fragment. These monoterpenoid substituents were chosen on the basis of literature data suggesting that the indicated compounds exhibit activity with respect to the nervous system in various animal models. On the basis of these ureas, imidazoline-2,4,5-triones were synthesised. These urea derivatives potentially possess lower lipophilic properties.
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