Simulation of Acute Lung Injury in Mice by Inhalation of Lipopolysaccharide Aerosol from Salmonella typhi Cells
N. A. ZHUKOVA1, A. M. BAKLANOV2, M. E. STEKLENEVA2, S. V. AN’KOV1,2, T. G. TOLSTIKOVA1,2, S. V. VALIULIN2
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia
2Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Keywords: aerosol, inflammation, pyrogenal, histology, mice, lungs
Abstract
Experimental acute lung inflammation in mice was modelled by inhalation of lipopolysaccharide aerosol from a Salmonella typhi microbial cell. It has been shown that inhalation aerosol administration of lipopolysaccharide (particle size 1.1±0.1 µm) for 60 min at a dose of 5.3 µg/kg leads to a pronounced haemodynamic and emphysematous reversible change in the lungs after 5-7 days, which is characteristic of acute lung inflammation.
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