Synthesis of Ureas Combining Adamantane and Monoterpenoid Fragments and Study of Their Activity Against the SARS-CoV-2 Viruses
E. D. MORDVINOVA1,2, E. S. MOZHAITSEV1, O. I. YAROVAYA1, K. YU. PONOMAREV1, E. V. SUSLOV1, D. N. SHCHERBAKOV1,2, A. V. ZAYKOVSKAYA2, O. V. PYANKOV2, N. F. SALAKHUTDINOV1
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2"State Research Center of Virology and Biotechnology "Vector", Federal Service for Surveillance on Consumer Rights Protection and Human Well-being, Koltsovo, Russia
Keywords: adamantane, monoterpenoids, coronaviruses, pseudoviral system, antiviral compounds
Abstract
A series of ureas containing adamantane and monoterpenoid residues has been synthesised. All compounds were tested in vitro using a pseudoviral system containing the S glycoprotein of the SARS-CoV-2 virus and infectious SARS-CoV-2 viruses of various strains on its surface. Compound 4a demonstrated high activity against four strains of SARS-CoV-2.
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