Comparative Pharmacokinetics of the Aerosol and Oral Forms of Pyrazinamide
S. V. AN'KOV1,2, T. G. TOLSTIKOVA1,2, S. V. VALIULIN2, A. A. ONISCHUK2, M. S. BORISOVA1,2, S. N. DUBTSOV2
1N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Keywords: Aerosol, pyrazinamide, pharmacokinetics, tuberculosis
Pages: 224-228
Abstract
Pharmacokinetics of the aerosol and oral forms of the delivery of the antituberculous drug pyrazinamide was investigated. The pharmacokinetic parameters for both forms of the medicinal preparation were demonstrated to be comparable. The advantages of aerosol delivery of pyrazinamide for therapeutic application are considered.
DOI: 10.15372/CSD2021300
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