ASSOCIATION OF rs662799 POLYMORPHISM WITH THE DEVELOPMENT OF ACUTE CEREBROVASCULAR ACCIDENT IN PATIENTS WITH CARDIOVASCULAR PATHOLOGY
D.A. Nikulin1, A.A. Chernova1, S.Yu. Nikulina1, A.N. Kelemeneva1, V.N. Maksimov1,2
1Krasnoyarsk State Medical University, 660022, Krasnoyarsk, Partizan Zheleznyak str., 1
2Research Institute of Internal and Preventive Medicine, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: cerebral circulatory disorders, ischemic stroke, supraventricular tachycardia, arterial hypertension, dyslipidemia, atherosclerosis, hemostasis, rs662799
Abstract
Objective: to study the association of rs662799 with the development of acute cerebrovascular accident in patients with cardiovascular diseases and risk factors for their development. Material and methods. The material of the study was presented by 260 inpatient patients with acute cerebrovascular accident at the age of [57.0; 51.0-62.0] years as a comparison group, 272 patients aged [55.0; 51.0-62.0] years were examined, this is the control group of our study. According to gender, all patients in the main group were divided into 157 men and 103 women. There were 170 men and 102 women in the control group. All patients of the main group, along with routine methods of examination, were analyzed by the blood coagulation system, from instrumental methods of investigation-electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily monitoring of blood pressure and heart rate, computed tomography of the brain. In patients of the main group, comorbid pathology was represented by the following cardiovascular diseases and risk factors: arterial hypertension (AG), paroxysmal supraventricular tachycardia, dyslipidemia, atherosclerosis of brachiocephalic arteries, disorders of the hemostasis system. The control group was investigated as part of the HAPIEE international project. Molecular genetic analysis was performed by real-time PCR. Statistical processing of the material was carried out using the Excel application kit and SPSS 22. The study was performed in accordance with Good Clinical Practice standards and the principles of the Helsinki Declaration. The study protocol was approved by the Ethics Committees of all participating clinical centers. Prior to inclusion in the study, written informed consent was obtained from all participants. Results. In all analyzed groups and subgroups of patients, an association was established between the rare G allele and the increased risk of PMC. The GG genotype showed significant associations with PMK in the main patient group, in the male subgroup, and in the AG subgroup. Conclusion. The AG genotype and the G allele rs662799 increase the risk of stroke in patients regardless of previous cardiovascular pathology and risk factors, including patients with arterial hypertension, supraventricular tachyarrhythmias, atherosclerosis of the brachiocephalic arteries, impaired lipid metabolism and the hemostatic system.
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