THE KLOTHO PROTEIN IN BLOOD IN MEN WITH ISCHEMIC HEART DISEASE AND ITS ASSOCIATION WITH A LIPID PROFILE
O.V. Timoshchenko, Yu.I. Ragino, E.M. Stakhneva, E.V. Kashtanova, Yu.P. Nikitin
Research Institute of Internal and Preventive Medicine - Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: белок Клото, атеросклероз, ишемическая болезнь сердца, липиды, Klotho protein, atherosclerosis, coronary heart disease, lipids
Abstract
Purpose of the study was to determine the quantitative content of Klotho protein in the blood of men with coronary heart disease in comparison with the control group and its association with the blood lipid profile. Material and methods. The study included 178 men, including 115 people aged 50-65 years (I age group) and 63 people over 80 years (II age group). The main group included 98 men with coronary heart disease, the average age was 61.1±11.4 years, the control group consisted of 80 men without coronary heart disease, and the average age was 68.1 ± 14.4 years. Klotho protein serum concentration was measured by ELISA. Results. Klotho’s protein level tends to decrease in people with coronary heart disease, its lower level is associated with an increased relative risk of coronary heart disease. In men with coronary heart disease, Kloto protein tends to increase with age, and men without coronary heart disease, on the contrary, decrease. In patients with coronary heart disease, an increase in Klotho protein in the blood is associated with an increase in the level of HDL-C and a decrease in the atherogenic coefficient. Conclusion. Thus, it can be assumed that Klotho protein in men with coronary heart disease exhibits anti-atherogenic properties.
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