Salsolidine and 1-Aryltetrahydroisoquinolines in the Aminomethylation of 6-Methyluracil and Their Biological Activity
SH. N. ZHURAKULOV, E. O. TERENTEVA, U. B. KHAMIDOVA, M. G. LEVKOVICH, Z. S. KHASHIMOVA, V. I. VINOGRADOVA, SH. S. AZIMOVA
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
Keywords: 6-метилурацил, 1-арилтетрагидроизохинолины, сальсолидин, конъюгаты, цитотоксичность, 6-methyluracil, 1-aryltetrahydroisoquinolines, salsolidine, conjugates, cytotoxicity
Pages: 155-160
Abstract
Mannich reaction of 6-methyluracil with salsolidine and substituted 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines was studied. The use of equimolecular amounts of reagents led to the production of new conjugates - 5-(1-(aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolyl)-2-methyl)-6-methylpyrimidin-2,4(1 Н ,3 H )-dions with 61-84 % yields. When studying the effect of these conjugates on the growth and viability of tumour cell lines (HeLa, HEp-2), it was found that the formation of tetrahydroisoquinoline derivatives with 6-methyluracil molecule does not contribute to the manifestation of cytotoxic effect.
DOI: 10.15372/CSD2020214
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