CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF ANCA-ASSOCIATED VASCULITIS: 7 YEARS OF EXPERIENCE IN DIAGNOSIS AND TREATMENT
a:2:{s:4:"TEXT";s:476:"Lyubov’ Mikhaylovna KUDELYA1, Yana Leonidovna MANAKOVA1, Ekaterina Sergeevna KHUSAINOVA2, Evgeniy Aleksandrovich DROBYAZGIN1, Anton Vadimovich KUTEPOV1, Alena Mikhaylovna GORBOVSKAYA2, Aleksandr Vladimirovich KOROBEYNIKOV2, Larisa Aleksandrovna BOGODEROVA2, Irina Aleksandrovna ZUBRITSKAYA2, Vitaliy Fanurovich KHUSAINOV1, Konstantin Igorevich SHCHERBINA2";s:4:"TYPE";s:4:"html";}
1Novosibirsk State Medical University of Minzdrav of Russia, State Novosibirsk Regional Clinical Hospital
oxy80@mail.ru
2State Novosibirsk Regional Clinical Hospital
ekhus88@yandex.ru
Keywords: АНЦА-ассоциированные васкулиты, микроскопический полиангиит, гранулематоз с полиангиитом, эозинофильный гранулематоз с полиангиитом, интерстициальное поражение легких
Abstract
The aim of the research is
to study nosological structure, features of kidney, lung damage, deaths
in patients with ANCA - associated vasculitis underwent medical
treatment in a multidisciplinary hospital. Material and methods.
Selection and subsequent retrospective analysis of the medical histories
of 38 inpatient patients observed in nephrological, rheumatological,
pulmonological and surgical thoracic departments for the period from
January 2012 to December 2018 were carried out. The disease main
clinical symptoms, variants of the X-ray picture, and causes of death
were assessed in the patients according to the clinical and laboratory
examination. Results and discussion. The most common diagnosis was
eosinophilic granulomatosis with polyangiitis (EGPA) - 16 cases;
microscopic polyangiitis was diagnosed in 11 patients, granulomatosis
with polyangiitis - in 9 persons. In 2 cases, ANCA-associated vasculitis
was diagnosed without specifying the nosological form. The most common
symptoms in patients with ANCA-vasculitis were fever, progressive
shortness of breath, weakness, artalgia, eosinophilia, which occurred
mainly in patients with EGPA. Among analyzed 38 cases, there were 6 men
and 32 women. The average age of patients was 50.72 ± 12.6 years. There
were 5 deaths and, in 2 cases, the outcome could not be clarified. All
deaths occurred during the first year from the disease onset caused by
infectious complications or severe manifestations of the main disease.
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