Home – Home – Jornals – Siberian Scientific Medical Journal 2020 number 1

The aim of the study is to
assess the effect of systemic and local risk factors on the rate of
glaucoma progression, the specificity and informative nature of
ophthalmological studies for assessment of the rate of glaucoma
progression. Material and methods. A retrospective analysis of the
medical case histories and outpatient charts of 217 patients (268 eyes)
for the period from 2014 to 2017 was conducted. The patients with
primary open-angle glaucoma having at least 5 Humphrey field-of-view
(24-2) studies and optic coherence tomography of the optic nerve disk
and retina with a guided progression analysis (GPA) function (SD-OCT)
were included in the study. The patients were divided into 2 groups:
with rapid progression (more than 1 dB per year, 144 eyes (103
patients)) and slow progression (less than 1 dB per year, 124 eyes (114
patients)). The data of standard ophthalmological methods of
investigation (visometry, ophthalmoscopy, biomicroscopy, measurement of
intraocular pressure (IOP) according to Maklakov) were additionally
analyzed. Demographic and clinical data were assessed: gender, age,
cornea central thickness, refraction, IOP, glucocorticosteroid intake,
cardiovascular diseases presence, arterial hypertension, arterial
hypotension, local hypotensive therapy. Results and discussion. The
analysis revealed the main risk factors in glaucoma progression, which
include age, cardiovascular diseases presence, high initial IOP values,
pronounced functional changes in the visual fields (lower mean
deviation), pseudoexfoliation syndrome