POTENTIAL BIOCHEMICAL MARKERS OF CHRONIC BRONCHITIS AND BRONCHIAL ASTHMA. CURRENT STATE OF THE PROBLEM
Evgeniy Alekseevich KURTUKOV, Yuliya Igorevna RAGINO
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics of SB RAS
Keywords: хроническая обструктивная болезнь легких, бронхиальная астма, биохимические маркеры, регулируемый активацией легочный хемокин, сурфактантный белок А, сурфактантный белок D, пентраксин-3, дефензин, О±1-антитрипсин, интерлейкин-19, макрофагальный белок воспаления, chronic obstructive pulmonary disease, bronchial asthma, biochemical markers, pulmonary activation regulated chemokine, surfactant protein A, surfactant protein D, pentraxin-3, defensin, alpha-1 antitrypsin, interleukin-19, macrophage inflammatory protein
Abstract
The literature review,
according to recent publications, systematizes modern ideas about new
biochemical markers of bronchopulmonary pathology, namely chronic
obstructive pulmonary disease, chronic bronchitis and bronchial asthma.
Information on potential biochemical markers associated with pathology
of the bronchopulmonary system is presented: pulmonary activation
regulated chemokine (chemokine ligand CCL20), surfactant proteins A and
D, pentraxin-3, defensins, alpha-1 antitrypsin, Clara cell protein,
interleukin-19, resistin-like molecules. For each biomolecule, its
characteristic, biological properties and effects are described, as well
as the results of experimental and clinical studies of its effects in
bronchopulmonary pathology, the association of elevated blood levels of a
biomolecule with clinical manifestations of diseases. It is concluded
that today there are a considerable number of new potential biomarkers
of the respiratory system diseases for early and effective diagnosis,
prevention and treatment of diseases, however, the effects of some of
them are either insufficiently studied or contradictory and require
further research, which is actively ongoing in the whole world and in
Russia.
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