LIPID INFILTRATION OF HEPATOCYTES IN THE MORPHOGENESIS OF CHRONIC HEPATITIS C
David L’vovich NEPOMNYASHCHIKH1, Olga Alexeevna POSTNIKOVA1, Ekaterina Eduardovna ABRAMOVA1, Olga Igorevna DOROVSKAYA2
1Novosibirsk State Medical University of Minzdrav of Russia
2State Novosibirsk Regional Clinical Hospital
Keywords: HCV-инфекция, липидосодержащие гепатоциты, генотипирование, HCV infection, lipid-containing hepatocytes, genotyping
Abstract
The aim of the study was to
investigate structurally functional features of lipidic infiltration of
hepatocytes in a morphogenesis of chronic hepatitis C. Material and
methods. A clinical and morphological study of 199 patients with HCV
infection markers (139 men and 60 women aged from 20 till 65 years) was
conducted. In all cases, a comprehensive study including analysis of
blood biochemical parameters, serological markers of HCV replication in
blood and liver, viremia level, number of the infected hepatocytes and
HCV genotypes was performed. Diagnostic complex included clinical,
biochemical, immunoserological methods. Results and discussion. The
results of the analysis of structural and functional features of
lipid-containing hepatocytes and indicators of replication of virus
particles of chronic hepatitis C are provided. For its reproduction HCV
enters into complex relationships with the metabolic apparatus of the
cell, in which lipid metabolism and related structures - lipid droplets
play an important role. The only structural marker that correlates with
indicators of virus replication is subcytolemmal small-vesicular lipid
infiltration, which can reflect a virus-induced increase in lipid
metabolism in the host cell for the effective production of infectious
active viral particles.
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