THE CHARACTERISTICS OF CYTOKINE STATUS IN PATIENTS WITH DEEP PHLEGMON OF THE NECK AND SECONDARY ACUTE MEDIASTINITIS UNDER DIFFERENT METHODS OF TREATMENT
Mariya Gennadievna PUSTOVETOVA1, Yuriy Vladimirovich CHIKINEV2,3, Evgeniy Aleksandrovich DROBYAZGIN2,3, Tatiana Sergeevna KUTEPOVA3
1Federal Centre for Cardiovascular Surgery n.a. S.G. Sukhanov
2Novosibirsk State Medical University of Minzdrav of Russia
3State Novosibirsk Regional Clinical Hospital
Keywords: глубокая флегмона шеи, медиастинит, лаваж озонированным раствором, про- и противовоспалительные цитокины, deep neck phlegmon, mediastinitis, lavage with ozonated solution, pro- and anti-inflammatory cytokines
Abstract
The aim of the study was to
improve the results of treatment of patients with deep neck phlegmon
and acute secondary mediastinitis. Material and methods. 81 case
histories of patients with deep neck phlegmon and 40 case histories of
patients with secondary acute mediastinitis who underwent examination
and treatment in the regional clinical hospital, Novosibirsk, for the
period from 2007 to 2017 were analyzed. The results of treatment were
evaluated by the dynamics of changes in the serum concentration of pro-
and anti-inflammatory cytokines TNF-α, IL-1ß, IL-6, IL-8, IL-4,
IL-1β/IL-4. Results and discussion. When applying the method of lavage
of deep neck and mediastinum cellular spaces with ozonated 0,9 % sodium
chloride solution, there is a 1,2-3-fold faster normalization of
cytokine status compared to standard lavage, which indicates a more
pronounced decrease in the intensity of the acute inflammatory process
in the postoperative period.
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