NEW ASPECTS OF THE USE OF PROTEIN TISSUE-SPECIFIC MARKERS IN THE ESTIMATION OF SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA
Mikhail Ivanovich VOEVODA1,2,3,4, Yuliya Igorevna RAGINO5, Konstantin Yuryevich NIKOLAEV1,4, Olga Sergeevna KHARLAMOVA5, Ekaterina Mikhaylovna STAKHNEVA5, Elena Vladimirovna KASHTANOVA5, Yana Vladimirovna POLONSKAYA5, Dinara Evgenyevna IVANOSHCHUK1,3, Margarita Vitalyevna KRUCHININA1,6, Vladimir Nikolaevich KRUCHININ7
1Research Institute of
Internal and Preventive Medicine - Branch of the Institute of Cytology
and Genetics of SB RAS
2Federal Research Center for Fundamental and
Translational Medicine
3The Federal Research Center Institute of
Cytology and Genetics of SB RAS
4Novosibirsk State University
5Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics of SB RAS
6Novosibirsk State Medical University
7Rzhanov Institute of Semiconductor Physics of SB RAS
Keywords: внебольничная пневмония, тяжелая пневмония, белки легочного сурфактанта А и D, сыворотка крови, парциальный корреляционный анализ, community-acquired pneumonia, severe pneumonia, pulmonary surfactant proteins A and D, blood serum, partial correlation analysis
Abstract
The purpose of the study
was to assess the associations of proteins of pulmonary surfactants A
(SP-A) and D (SP-D) with the severity of community-acquired pneumonia.
Material and methods. A survey of 188 patients diagnosed with
community-acquired pneumonia (CAP). The average age of the examined
patients was 54.3 ± 16.5 years (M ± SD). In 102 patients (54.3 %) severe
CAP was verified. All patients underwent clinical, functional,
diagnostic and laboratory studies. Results and discussion. It was
determined that SP-A and SP-D content was significantly higher in
patients with severe CAP compared to patients with a mild course of this
disease. The direct association of severe CAP with an elevated SP-AP
level, directly associated with an increase in the concentration of
C-reactive protein in the blood and erythrocyte sedimentation rate, have
been confirmed in early studies. Using partial correlation analysis, it
was established that the severe course of CAP is directly related to
SP-A ( r = 0.221; p = 0.003) and SP-D content ( r = 0.262; p < 0.001)
regardless of age, smoking, and body weight. Thus, direct associations
of SP-A and SP-D with a severe course of CAP reflect the high
pathogenetic significance of these protective factors in infectious lung
damage.
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