STIMULATION OF REPARATIVE REGENERATION OF SUPPORTING TISSUE UNDER CONDITIONS OF DELAYED APPOSITION OF FRAGMENTS
Svetlana Alexandrovna LEPEKHOVA1, Guanda QIAO1, Oleg Aronovich GOLDBERG2, Nikolay Valer`evich TISHKOV2, Lida QIAO3, Ilya Sergeevich KURGANSKIY1,2, Pavel Olegovich INOZEMTSEV1, Lyudmila Ivanovna FEDOROVA1
1Irkutsk Scientific Center of SB RAS 2Irkutsk Scientific Center of Surgery and Traumatology 3Irkutsk City Clinical Hospital № 1
Keywords: регенерация, ложный сустав, голень, морфометрия костной ткани, биологически активные точки, regeneration, pseudarthrosis, shin, bone morphometry, biologically active points
Abstract
The study is devoted to
reparative regeneration of supporting tissue in the area of the defect
using the methods of acupuncture with stimulation of biological active
points when modeling delayed apposition of fragments. Material and
methods. The work was performed using laboratory animals of the
Chinchilla rabbits, at the age of 6 months. The delayed apposition of
shin bone fragments was simulated in all animals. In the dynamics of the
study, an assessment of radiological and morphological changes in the
area of the bone defect was performed. After the fragments were compared
and fixed using animal randomization methods, the animals were divided
into two groups - the control and the main group, in which the
biologically active points were stimulated. Results and discussion. The
evaluation of the supporting tissue regeneration in the defect zone
under the influence of proposed biologically active points combination
by the method of acupuncture within the conditions of delayed apposition
of shin bone fragments has revealed physiological change of
regeneration phases with the formation of differentiated bone tissue and
bone marrow elements to the 50th day of the study. The 2 fold
predominance of bone tissue, 2 fold - the bone marrow substance, a
decrease in cartilage tissue, the absence of fibrous connective tissue
have been revealed compared with the control group, where the slowdown
in the physiological change of regeneration phases and the formation of
regenerate supporting tissue in the form of pseudarthrosis have been
revealed.
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