MORPHOLOGICAL CHARACTERISTICS OF TISSUE MICROREGION OF THE THYROID GLAND AT EXPERIMENTAL HYPOTHYROIDISM
Olga Vladimirovna GORCHAKOVA1, Vladimir Nikolaevich GORCHAKOV2,3, Georgiy Anatolevich DEMCHENKO4, Serik Nauryzbaevich ABDRESHOV4
1Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics SB RAS
2Research Institute of
Clinical and Experimental Lymphology - Branch of the Institute of
Cytology and Genetics SB RAS
3Novosibirsk State University
4Institute of Human and
Animal Physiology of the Scientific Committee of the Ministry of
Education and Science of the Republic of Kazakhstan
Keywords: щитовидная железа, тканевой микрорайон, гипотиреоз, thyroid gland, tissue microregion, hypothyroidism
Abstract
Research purpose was to
study the structures of the tissue microregion of the thyroid gland at
an experimental hypothyroidism. Material and methods. The hypothyroidism
model was created by mercazolilum intake at a dose of 5 mg/100 g of
body mass for a month. The structure of tissue area (follicle,
thyrocyte, interfollicular space) with morphometry and calculation of
the integral indicators of the thyroid gland functional activity have
been investigated by the light-optical and ultrastructural methods.
Results and discussion. The morphophysiological structure of the thyroid
gland is a tissue microregion. It unites a group of follicles and
interfollicular space. The structure of the tissue miroregion have
features of structural response to merkazolilum intake. The thyrostatic
remedy changes the follicular organization of the thyroid gland to the
predominance of small and medium follicles with signs of alteration.
Thyrocytes have expansion and deformation of the granular endoplasmic
reticulum cisterns, formation of intracellular colloid, reduction in the
number of lysosomes and mitochondrions with their disorganization. The
ratio of the area of the follicular epithelium, colloid and stroma
changes at hypothyroidism. The portion of interstitial increases, there
is an accumulation of tissue fluid because of weakening of a lymphatic
drainage. Blood and lymphatic microvessels react by reducing the volume
density to mercazolilum intake. Conclusion. The merkazolilum
thyreostatics effects on morphology and metabolic and transport
processes in tissue microregion. It testifies to decrease of thyroid
function and the creation of hypothyroidism adequate model.
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