MIRNA AS DIAGNOSTIC MARKERS OF ACUTE MYOCARDIAL INFARCTION AND HEART MUSCLE REMODELING
D.E. Ivanoshchuk1,2,3, A.S. Rozanov1, P.S. Orlov1,2,3, S.V. Mikhaylova1, E.V. Shakhtshneyder1,2,3, M.V. Kruchinina2, M.I. Voevoda1,2,3
1Federal Research Institute of Cytology and Genetics of SB RAS, 630090, Novosibirsk, Akademik Lavrentiev av., 10
2Research Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
3Novosibirsk State University, 630090, Novosibirsk, Pirogov str., 2
Keywords: myocardial infarction, remodeling, miRNA, diagnostic markers, RNA, gene expression
Abstract
Cardiovascular diseases, in particular myocardial infarction (MI), are one of the most common causes of death in the world. Today, a significant problem for assessing of MI and post-infarction complications risks is the insufficient sensitivity and prognostic values of modern methods and markers. Therefore, the identification of new markers with high specificity and sensitivity is an important task. Recently, much attention has been paid to the study of extracellular RNAs, which are relatively stable in biological fluids. In this article, we overviewed some miRNAs, which are considered as potential markers for the diagnosis of MI and prediction of its adverse effects.
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