CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION
A.S. Vorobyev1,2, L.V. Kovalenko1, K.Yu. Nikolaev2,3, I.A. Urvantseva1,2, T.O. Simonyan1, M.I. Rudenko1
1Surgut State University, 628412, Surgut, Lenin av., 1
2District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery, 628403, Surgut, Lenin av., 69/1
3Research Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: myocardial infarction, myocardial remodeling, TIMP-1, prediction
Abstract
In this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of postinfarction LV myocardial remodeling. In patients who had serum concentrations of TIMP-1 over the established cut-off value (144.0 ng/ml), the risk of post-infarction LV remodeling was 3.33 times higher than in individuals who had TIMP-1 levels lower this value. Thus, TIMP-1 is a reliable prediction biomarker of adverse left ventricular myocardial remodeling in Q-wave MI.
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