ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS
E.Ya. Zhuravskaya1, T.I. Savchenko2, O.V. Chankina2, Ya.V. Polonskaya1, E.V. Sadowski1, E.M. Stakhneva1, Yu.I. Ragino1, A.M. Chernyavskii3
1Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Voevodsky Institute of Chemical Kinetics and Combustion of SB RAS, 630090, Novosibirsk, Institutskaya str., 3
3National Medical Research Center named academician E.N. Meshalkin of Minzdrav of Russia, 630055, Novosibirsk, Rechkunovskaya str., 15
Keywords: coronary atherosclerosis, atherosclerotic plaque, mineral elements, calcium, zinc.
Pages: 30-34
Abstract
Purpose: to determine the content of mineral elements in the homogenates of atherosclerotic plaques of human coronary arteries. Methods: research material – homogenates of samples of atherosclerotic plaques of coronary arteries obtained during coronary bypass surgery. The concentration of chemical elements Ca, Pb, Fe, Cu, Zn, Br, Sr, Zr in the homogenates of atherosclerotic plaques was determined by x-ray fluorescence analysis using synchrotron radiation (SRXRF). Results: in all the studied samples the predominant presence of Ca was observed, in stable plaques 1791.93±3042.25 µg/ml, in unstable atherosclerotic plaques 2024.33±1267.13 µg/ml.Association of Ca with Fe (r = 0.798; p < 0.01), Zn (r = 0.963; p < 0.01) and Sr (r = 0.981; p < 0.01) in the atherosclerotic focus was revealed. No significant difference between the measured elements in stable and unstable plaques was found. Conclusion: the method x-ray fluorescence analysis using synchrotron radiation revealed some patterns of the mineral composition of an atherosclerotic plaque of a human. The main mineral component of the atherosclerotic plaque is calcium, with a tendency to increase the concentration of the element in the unstable focus. Minor components-iron, zinc, strontium are associated with calcium. In this case, iron tends to reduce the concentration in an unstable atherosclerotic focus, and the concentration of strontium and zinc does not change significantly.
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