ASSOCIATION OF ATHEROSCLEROSIS-ASSOCIATED CARDIOVASCULAR RISK FACTORS AT DIFFERENT LEVELS OF PROLACTIN IN WOMEN OF REPRODUCTIVE AGE
S.M. Voevoda1,2, L.V. Shcherbakova1, D.V. Denisova1, E.V. Shakhtshneyder1, Yu.I. Ragino1, E.M. Stakhneva1, O.D. Rymar1
1Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Federal Research Center Institute of Cytology and Genetics of SB RAS, 630090, Novosibirsk, Academician Koptyug av., 2
Keywords: пролактин, гиперпролактинемия, атеросклероз, prolactin, hyperprolactinemia, atherosclerosis
Abstract
Objective: to study the association of prolactin with indicators of carbohydrate and lipid metabolism in women of reproductive age 25-45 years. Materials and methods: Clinical and laboratory examination of a random representative sample of women 25-45 years old. The random number method formed a sample of 416 women, who determined the level of PRL. The average age of the examined women was 36.0 ± 6.2 years. Formed a group of women who have an elevated level of PRL (prolactin> 19.5 ng/ml ( n = 95)). Statistical evaluations included a descriptive analysis of the numerical characteristics of the features (mean value, standard deviation). The studied parameters are divided into quartiles by the level of prolactin. The analysis of variance was performed using the multiple comparison method. Results: There is a decrease in the average values of fasting plasma glucose, TC, LDL in women from 1 to 4 quartile of PRL. The mean values of cholesterol-HDL increase from 1 to 3 quartile of PRL, not reaching statistical significance. BMI has minor changes between quartiles. In the group of women with a normal level of PRL with a flat analysis of the data of biochemical blood analysis, indicators of blood pressure, BMI, and waist circumference, lower levels of total cholesterol and LDL were obtained in 4 prolactin. When analyzing the studied parameters in women with a PRL level of more than 19.5 ng/ml, there is an increase in TG, BMI and waist circumference values from 1 to 4 quartile of PRL. Fasting plasma glucose TC, LDL, HDL increase from 1 to 4, however, the difference does not reach statistical significance. Conclusion: Analyzing our own and literature data, we can conclude that hyperprolactinemia can increase the risk of atherosclerotic lesions of the cardiovascular system, both through direct effects on lipids and atherosclerotic plaques, and indirectly, affecting metabolic disorders leading to obesity, development insulin resistance and changes in glucose metabolism, which in turn can affect the development of atherosclerotic lesions. The features and mechanisms of PRL effects on metabolism are very complex and need further study.
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