IMPACT OF GENDER AND AGE ON IN-HOSPITAL OUTCOMES OF CORONARY ARTERY BYPASS GRAFTING
I.I. Zhidkova1, I.A. Shibanova2, S.V. Ivanov1, A.N. Sumin1, O.L. Barbarash1, I.V. Samorodskaya3
1Scientific Research Institute for Complex Issues of Cardiovascular Diseases, 650002, Kemerovo, Sosnovy boul., 6
2Kemerovo Regional Clinical Cardiological Clinic Named after Academician L.S. Barbarash, 650002, Kemerovo, Sosnovy boul., 6
3State Research Center for Preventive Medicine of the Ministry of Health of Russia, 101990, Moscow, Petroverigsky pereulok, 10
Keywords: коронарное шунтирование, возрастные и гендерные факторы, госпитальные осложнения, комбинированный исход, coronary artery bypass grafting, age and gender characteristics, hospital complications, combined outcome
Abstract
Aim. To evaluate the impact of age and gender on in-hospital outcomes of coronary artery bypass grafting (CABG) in patients with coronary artery disease. Methods. 538 (79.10 %) men and 142 (20.90 %) women ( n = = 680) in the CABG registry of the Research Institute for Complex Issues of Cardiovascular who were referred to CABG in the period from 2011 to 2012 were retrospectively reviewed to assess the prevalence of comorbidities and estimate the in-hospital outcomes. The mean age of patients was 59.12 ± 7.98 (33 to 78 years). All patients were assigned to 4 age groups: Group 1 - <50 years, Group 2 - 51-60 years, Group 3 - 61-70 years, Group 4 - >70 years. The statistical analysis was performed using the software package SPSS 20.0.1. A p value of <0.05 was considered statistically significant. Results. Women were commonly older than men and had a positive history of hypertension, chronic heart failure and higher angina class, obesity, type 2 diabetes, impaired glucose tolerance, non-ulcerative lesions of the gastrointestinal (GI) tract (gastritis, cholecystitis and / or pancreatitis). The male group was superior to the female group in the number of smokers and prior myocardial infarction. The incidence of first detected atrial fibrillation, atrial flutter, as well as ischemic strokes, congestive pneumonia increased with aging in both men and women within the in-hospital period. However, women, particularly from the younger age group (<50 years), more frequently suffered from ischemic strokes, GI bleedings, exacerbation of erosive gastritis, compared with men. Women from the older age group commonly had hydrothorax requiring pleural puncture, surgical wound healing complications, and exacerbation or / the first detected duodenal and / or stomach ulcers, compared to men. Conclusion: Female gender is associated with a significantly higher rate of the in-hospital complications compared to men. However, the impact of gender is mediated by age differences between men and women undergoing CABG.
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