THE KLOTHO PROTEIN CONTENT AND LIPID BLOOD PROFILE BY AGE IN MEN 20-65 YEARS
O.V. Timoshchenko, Yu.I. Ragino, E.M. Stakhneva, Yu.V. Shchepina, E.V. Kashtanova, L.D. Latyntseva
Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: белок Клото, старение, липиды, ЛП(а), коэффициент атерогенности, Klotho protein, aging, lipids, Lp(a), atherogenic index
Abstract
Purpose of the study. To study the special of protein Klotho and lipid profile in blood in young men and middle-aged men. Material and methods. Men ( n = 71) at the age of 20-35 years old (I group) and 50-65 years old (II group) were examined.Patients underwent general clinical, anthropometric, biochemical and instrumental examinations. The concentration in the blood serum of the Klotho protein was measured by the immunoenzyme technique ELISA. The content of total cholesterol and its components was determined by enzymatic methods. Results. The mean serum of protein Klotho in men I group was 687.6 ± 222.8 pg/ml, in II -1051.6 ± 121.5 pg/ml. The differences are significant - 1.5 times, but statistically unconvincing ( p = 0.161). A positive correlation was obtained between the protein Klotho and lipid metabolism indices: TC, TG, VLDL,non-LDL cholesterol, atherogenic index and inverse correlation with HDL-cholesterol. Conclusion.There is a tendency to increase with age the content of lipid components in the blood - non-HDL cholesterol, LDL-cholesterol, VLDL and atherogenic index. It can be concluded that, at the age of 20-65 years, the level of protein Klotho remains a tendency to increase in parallel with an increase in lipid parameters, in particular, the atherogenic index.
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