THE ASSOCIATION OF RISK FACTORS FOR ATHEROSCLEROSIS AND POLYMORPHISM OF THE ADRB1 GENE WITH PRO-ARRHYTHMIC ELECTROCARDIOGRAPHIC PATTERNS IN THE GENERAL POPULATION OF NOVOSIBIRSK
A.A. Kuznetsov, A.A. Kuznetsova, T.I. Batluk, V.N. Maksimov, M.I. Voevoda, S.K. Malyutina, Yu.P. Nikitin
Institute of Internal and Preventive Medicine - Branch of Feseral Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: факторы риска, полиморфизм гена ADRB1, Бругада-паттерн, ранняя реполяризация, фрагментация QRS, общая популяция, risk factors, ADRB1 gene polymorphism, Brugada-pattern, early repolarization, QRS fragmentation, general population
Abstract
The dangerous electrophysiological shifts in the myocardium, with the exception of rare congenital canalopathies, are overwhelmingly secondary, being a consequence of various pathological conditions. These processes, in turn, can also be genetically determined. Thus, the association of indices of ventricular repolarization with polymorphism of adrenoreceptor genes is shown. The electrical instability of the myocardium, apparently, has a multigenic and multifactorial basis. The aim of the study was to study the relationship between the risk factors and the polymorphism of the ADRB1 gene with pro-arrhythmic electrocardiographic patterns in the general population of Novosibirsk. Material and methods. Materials of epidemiological study of the general population of Novosibirsk under the WHO project «MONICA» (a sample of 831 men aged 25-64 years) were used. For genetic research 195 people were randomly selected. ECG-patterns were identified in a 30 % subsample - 261 people. The number of people with both genetic and electrocardiographic data was 105 people. According to the WHO criteria, components of the metabolic syndrome were identified. The A145G (rs1801252) polymorphism of the ADRB1 gene was determined. The Brugada, early repolarization, QRS fragmentation patterns were detected according to current criteria. The multivariate general linear model (GLM) were applied. Results. The QRS fragmentation was independently associated with obesity ( p = 0.014), increased TG level ( p = 0.040), decreased HDL cholesterol level ( p = 0.00079) and polymorphism of the ADRB1 gene (p = 0.00019). Conclusion. The integral approach is advisable in analyzing the genetic, metabolic and electrophysiological factors causing the electrical instability of the myocardium.
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