Synthesis and Biological Activity of Mechanocomposites of Piroxicam with Different Molecular Weight Chitosan
T. P. SHAKHTSHNEIDER1,2, S. A. MYZ1, A. S. MEDVEDEVA3, L. P. SAFRONOVA3, T. M. KONSHINA4, A. A. BURLUTSKAYA4, and G. V. GOLDOBINA4
1Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
E-mail: shah@solid.nsc.ru
2Novosibirsk State University, Novosibirsk, Russia
3A. E. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia
4Perm State Medical University named after Academician E.A. Wagner, Perm, Russia
Keywords: piroxicam, chitosan, mechanocomposites, mechanochemical activation, analgesic activity
Pages: 561-567
Abstract
Mechanocomposites of piroxicam with different molecular weight chitosan were produced. They possessed elevated rates of release of piroxicam into a solution. Anti-inflammatory and analgesic activities of the resulting composites were explored. Piroxicam-chitosan mechanocomposites were superior analgesics compared to piroxicam.
DOI: 10.15372/CSD20180517
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