NEW METHOD OF DRUGS DELIVERY TO THE OCULAR SURFACE
Tat’yana Nikolaevna SAFONOVA, Ol’ga Vladimirovna GLADKOVA, Nataliya Pavlovna KINTYUKHINA
Scientific Research Institute of Eye Diseases
Keywords: лечебная мягкая контактная линза, циклоспорин А, спектрометрия, хроматография, therapeutic soft contact lens, cyclosporin A, spectrometry, chromatography
Abstract
The effectiveness of topical application of various drugs in ophthalmology is no more than 3 % due to the presence of anatomical and physiological barriers. The therapeutic effect accomplishment is possible with increasing concentration or multiplicity of drug use. The article presents the results of the development of a new type of therapeutic contact lens for the deposition of medications in order to shorten the periods of treatment and to obtain a result without repeated manipulation. The quantitative evaluation of the drug content in the lens is given. The dynamics of the release of the drug substance from the lens was determined by the method of spectrometry. Practically complete elimination of the drug from the soft contact lens (SCL) depot (both on the outer and inner surfaces of the lens) is observed on the 13-14 day. With the help of the chromatography method, the absence of drug diffusion from saturated SCL during storage in buffer solutions was proved. The design features of the lens: a depot with a drug on the external and / or internal surface of the therapeutic SCL allow for a dosed and directed effect on various structural components of the oculer surface. The presence of a transparent optical center allows maintaining high visual functions. If it is necessary to prolong therapy, it is possible to re-saturate the same SCL with a drug substance.
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