Reagents Based on Silicon Nanoparticles and Therapeutic Nucleosides for Imaging and Targeted Exposure on Tumor Tissues
I. YU. SERPOKRYLOVA, L. S. KOROLEVA, T. S. GODOVIKOVA, V. N. SILNIKOV
Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia
Keywords: тераностик, наночастицы диоксида кремния, химическая модификация, рекция алкин-азидоциклоприсоединения, терапевтические нуклеозиды, визуализация опухоли, theranostics, silicon dioxide nanoparticles, chemical modification, reaction of azide-alkyne Huisgen cycloaddition, therapeutic nucleosides, visualization of the tumor
Pages: 292-303
Abstract
In recent years, as a result of research aimed at minimizing the harmful adverse effect on the patient in the treatment of cancer, a new class of drugs has been formed that provide both therapeutic effects on the tumor and its visualization. These drugs are called teranostics, and the methodology for their use is defined as teranistics, an area of integrated medicine that combines therapy and diagnosis, when doctors use one technology for both diagnosis and treatment of the disease during the general procedure. These drugs are called teranostics, and the methodology for their use is defined as teranostics, an area of integrated medicine that combines therapy and diagnosis, when use one technology for both diagnosis and treatment of the disease during the general procedure. A wide variety of nanostructures for teranics, represented by different nanostructures: carbon nanotubes, magnetic, gold, polymeric nanoparticles, nanoparticles of silicon dioxide, etc., opens wide prospects for their use in oncology. This review focuses on recent advances in the development of approaches to the development of theranostics based on silicon nanocomposites, where the therapeutic nucleosides serve as the main therapeutic agents. On the basis of the critical analysis, generalized conclusions were made about possible ways to increase the effectiveness of therapy, as well as the possibilities of visualization of antitumor drugs based on the nanoconstructions examined.
DOI: 10.15372/CSD20180307
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