Quantification of the Efficiency of Prostaglandin dl-PGF2О± Synthesis
R. F. TALIPOV1, I. V. VAKULIN1, R. R. SAYAHOV1, M. M. KANCHURINA1, G. YU. ISHMURATOV2
1Bashkir State University, Ufa, Russia
2Ufa Institute of Chemistry, RAS, Ufa, Russia
Keywords: лекарственный препарат, органический синтез, количественная оценка эффективности синтеза, drug, organic synthesis, synthesis efficiency quantification
Pages: 194-199
Abstract
Selection of the optimum synthetic path to the active ingredient for any drug is a complex task. The lack of computational methods for performance assessment of chemical transformations does not allow evaluating the proposed synthesis options and efficiently using computational methods in their development. The method of quantification of syntheses efficiency considering changes in structural complexity of organic compounds, reaction conditions and results is developed.
DOI: 10.15372/CSD20180212
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